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Cancer Diagnosis Program (CDP) — Biorepositories & Biospecimen Research Branch (BBRB) Cancer Diagnosis Program (CDP) Biorepositories & Biospecimen Research Branch (BBRB)
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Last Updated: 10/29/21

Current Funding Opportunities

Visit this page often to find new biospecimen-related funding opportunities from the NCI Biorepositories and Biospecimen Research Branch and other NIH Research Programs.

Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trials Not Allowed)


Posted date: October 22, 2021
Open date (Earliest submission date): December 11, 2021

This Funding Opportunity Announcement (FOA) will support extramural research to investigate and mitigate challenges facing clinical assay development and subsequent analytical validation due to preanalytical variability in tumor tissue biopsies and blood biospecimens utilized as “liquid biopsies.” Extramural research funded under this FOA may include investigations of preanalytical variability associated with the procurement and study of small biopsies (core biopsies, small excision samples), pleural aspirates, and blood utilized for liquid biopsies. Investigator-designed experiments will explore how different biospecimen preanalytical conditions affect emerging and clinically relevant biomarkers quantified by a variety of testing platforms. The results from this research program will improve the understanding of how analytical quantification of clinically relevant biomarkers is affected by variation in biospecimen collection, processing, and storage procedures. The overall goal is to expedite biomarker clinical assay development through evidence-based standardization of biopsy handling practices.

CDP contact:
Dr. Abhi Rao, 240-276-5715,
Dr. Lokesh Agrawal, (240) 276-5718,

Past Funding Opportunities

A complete list of past funding opportunities is available in the Past Funding Opportunities section.

Complementary Funding Opportunities

A list of complementary funding opportunities is available in the Complementary Funding Opportunities section.