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Cancer Diagnosis Program (CDP) — Biorepositories & Biospecimen Research Branch (BBRB) Cancer Diagnosis Program (CDP) Biorepositories & Biospecimen Research Branch (BBRB)
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Last Updated: 07/03/24

BBRB Staff Publications

A list of staff publications in peer-reviewed journals can be viewed below.

Authors Title Citation General Topic
Sobin L, Barcus M, Branton PA, Engel KB, Keen J, Tabor D, Ardlie KG, Greytak SR, Roche N, Luke B, Vaught J, Guan P, Moore HM. Histologic and Quality Assessment of Gentoype-Tissue Expression (GTEx) Research Samples: A Large Postmortem Tissue Collection 2024 May 27. Online ahead of print. doi: 10.5858/arpa.2023-0467-OA GTEx
Branton PA, Sobin L, Barcus M, Engel KB, Greytak SR, Guan P, Vaught J, Moore HM. Notable Histologic Findings in a "Normal" Cohort: The National Institutes of Health Genotype-Tissue Expression (GTEx) Project 2024 April 27. Online ahead of print. doi: 10.5858/arpa.2023-0468-OA GTEx
Greytak SR, Engel KB, Hoon DSB, Elias K, Lockwood CM, Guan P, Moore HM. Evidence-based procedures to improve the reliability of circulating miRNA biomarker assays Clin Chem Lab Med. 2023 May 3; 62 (1): 60-66. doi: 10.1515/cclm-2023-0131 Best Practices
Li J, Greytak SR, Guan P, Engel KB, Goerlitz DS, Islam M, Varghese RS, Moore HM, Ressom HW. Formalin Fixation, Delay to Fixation, and Time in Fixative Adversely Impact Copy Number Variation Analysis by aCGH Biopreserv Biobank. 2023 Aug; 21(4): 407-416. doi: 10.1089/bio.2022.0036 Biospecimen Pre-analytical Variables
Wehmas LC, Wood CE, Guan P, M Gosink, SD Hester. Organocatalyst treatment improves variant calling and mutant detection in archival clinical samples Sci Rep 2022 Apr 20;12(1):6509 DOI: 10.1038/s41598-022-10301-0 Biospecimen Pre-analytical Variables
Heidi L. Rehm, Angela J.H. Page, Lindsay Smith, Esmeralda Casas-Silva, et al. GA4GH: International policies and standards for data sharing across genomic research and healthcare Cell Genomics, Volume 1, Issue 2, 2021 Nov 10, 100029, ISSN 2666-979X. doi: 10.1016/j.xgen.2021.100029 Policy and standards
Bagchi, A, Madaj, Z, Engel, KB, Guan, P, Rohrer, DC, Valley, DR, Wolfrum, E, Feenstra, K, Roche, N, Hostetter, G, Moore, HM, & Jewell, SD. Impact of preanalytical factors on the measurement of tumor tissue biomarkers using immunohistochemistry J Histochem Cytochem. 2021 May; 69(5): 297-320. DOI: 10.1369/0022155421995600. PMID: 33641490. Biospecimen Pre-analytical Variables
GTEx Consortium. The GTEx Consortium atlas of genetic regulatory effects across human tissues Science. 2020 Sep 11;369(6509):1318-1330. doi: 10.1126/science.aaz1776. GTEx
Greytak SR, Engel KB, Parpart-Li S, Murtaza M, Bronkhorst AJ, Pertile MD, Moore HM. Harmonizing Cell-Free DNA Collection and Processing Practices through Evidence-Based Guidance Clin Cancer Res. 2020 Jul 1; 26(13):3104-3109. doi: 10.1158/1078-0432.CCR-19-3015 Best Practices
Carithers LJ, Agarwal R, Guan P, Odeh H, Sachs MC, Engel KB, Greytak SR, Barcus M, Soria C, Lih CJ, Williams PM, Branton PA, Sobin L, Fombonne B, Bocklage T, Andry C, Duffy ER, Sica G, Dhir R, Jewell S, Roche N, Moore HM. The Biospecimen Preanalytical Variables Program: A Multiassay Comparison of Effects of Delay to Fixation and Fixation Duration on Nucleic Acid Quality. Arch Pathol Lab Med. 2019 Sept; 143(9):1106-1118. doi: 10.5858/arpa.2018-0172-OA Biospecimen Pre-analytical Variables
Yizhak K, Aguet F, Kim J, Hess JM, Kübler K, Grimsby J, Frazer R, Zhang H, Haradhvala NJ, Rosebrock D, Livitz D, Li X, Arich-Landkof E, Shoresh N, Stewart C, Segrè AV, Branton PA, Polak P, Ardlie KG, Getz G. RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues Science. 2019 June 07; 364(6444). doi:10.1126/science.aaw0726 GTEx
Jones W, Greytak S, Odeh H, Guan P, Powers J, Bavarva J, Moore, HM. Deleterious effects of formalin-fixation and delays to fixation on RNA and miRNA-Seq profiles Science Reports. 2019 May; 6980 (9). doi: 10.1038/s41598-019-43282-8 Biospecimen Pre-analytical Variables
Rao A, Vaught J, Tulskie B, Olson D, Odeh H, McLean J, Moore HM. Critical Financial Challenges for Biobanking: Report of a National Cancer Institute Study. Biopreserv Biobank. 2019 Apr;17(2):129-138. doi: 10.1089/bio.2018.0069. Biobank financial considerations
Mathieson W, Mommaerts K, Trouet JM, Mathay C, Guan P, Carithers LJ, Rohrer D, Valley DR, Blanski A, Jewell S, Moore HM, Betsou F. Cold Ischemia Score: An mRNA Assay for the Detection of Extended Cold Ischemia in Formalin-Fixed, Paraffin-Embedded Tissue. J Histochem Cytochem. 2019 Mar;67(3):159-168. doi: 10.1369/0022155418819967 Biospecimen Pre-analytical Variables
Ammerlaan W, Trouet J, Sachs MC, Guan P, Carithers L, Lambert P, Frasquilho S, Antunes L, Kofanova O, Rohrer D, Valley DR, Blanski A, Jewell S, Moore H, Betsou F. Small Nucleolar RNA Score: An Assay to Detect Formalin-Overfixed Tissue. Biopreserv Biobank. 2018 Dec; 16(6): 467-476. doi: 10.1089/bio.2018.0042. Biospecimen Science
Lockhart NC, Weil CJ, Carithers LJ, Koester SE, Little AR, Volpi S, Moore HM, Berkman BE. Development of a consensus approach for return of pathology incidental findings in the Genotype-Tissue Expression (GTEx) project. J Med Ethics. 2018 Sep;44(9):643-645. GTEx
Ossandon MR, Agrawal L, Bernhard EJ, Conley BA, Dey SM, Divi RL, Guan P, Lively TG, McKee TC, Sorg BS, Tricoli JV. Circulating Tumor DNA Assays in Clinical Cancer Research. J Natl Cancer Inst. 2018 Sep 1; 110(9):929-934. Biospecimen Science
Greytak SR, Engel KB, Moore HM. Maximizing the Utility of Archival Formalin-Fixed Paraffin-Embedded Blocks for Nucleic Acid Analysis. Biopreserv Biobank. 2018 Aug;16(4):245-246. Biospecimen Science
Greytak SR, Engel KB, Zmuda E, Casas-Silva E, Guan P, Hoadley KA, Mungall AJ, Wheeler DA, Doddapaneni HV, Moore HM. National Cancer Institute Biospecimen Evidence-Based Practices: Harmonizing Procedures for Nucleic Acid Extraction from Formalin-Fixed, Paraffin-Embedded Tissue. Biopreserv Biobank. 2018 Aug;16(4):247-250. Best Practices
Greenberg B, Christian J, Meltzer Henry L, Leavy M, Moore HM. Research White Paper; Addendum to “Registries for Evaluating Patient Outcomes: A User’s Guide, Third Edition”; part of an eBook entitled “21st Century Patient Registries” AHRQ (Agency for Health Research Quality) Publication No. 17(18)-EHC014-EF. February 2018. Biospecimen Science
Agrawal L, Engel KB, Greytak SR, Moore HM. Understanding preanalytical variables and their effects on clinical biomarkers of oncology and immunotherapy. Semin Cancer Biol. 2017 Dec 16. pii: S1044-579X(17)30248-1. Biospecimen Science
Moore HM, Rao A, Branton PA, and Guan P are collaborators. Genetic effects on gene expression across human tissues. Nature. 2017 Oct 11;550(7675):204-213. GTEx
Odeh H, Miranda L, Rao A, Vaught J, Greenman H, McLean J, Reed D, Memon S, Fombonne B, Guan P, Moore HM. The Biobank Economic Modeling Tool (BEMT): Online Financial Planning to Facilitate Biobank Sustainability. Biopreserv Biobank. 2015 Dec;13(6):421-9. Economics of Biobanking
Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA, Compton CC, DeLuca DS, Peter-Demchok J, Gelfand ET, Guan P, Korzeniewski GE, Lockhart NC, Rabiner CA, Rao AK, Robinson KL, Roche NV, Sawyer SJ, Segrè AV, Shive CE, Smith AM, Sobin LH, Undale AH, Valentino KM, Vaught J, Young TR, Moore HM; GTEx Consortium. A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project. Biopreserv Biobank. 2015 Oct;13(5):311-9. GTEx
GTEx Consortium. Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science. 2015 May 8;348(6235):648-60. GTEx
Greytak SR, Engel KB, Bass BP, Moore HM. Accuracy of Molecular Data Generated with FFPE Biospecimens: Lessons from the Literature Cancer Res. 2015 Apr 15;75(8):1541-7. Biospecimen Research
Keen JC, Moore HM. The Genotype-Tissue Expression (GTEx) Project: Linking Clinical Data with Molecular Analysis to Advance Personalized Medicine J Pers Med. 2015 Feb 5;5(1):22-9. GTEx
Simeon-Dubach D, Moore HM. BIO comes into the cold to adopt BRISQ Biopreserv Biobank. 2014 Aug; 12 (4): 223-4  
Moore HM. Moving toward biospecimen harmonization with evidence-based practices Biopreserv Biobank. 2014 Apr; 12 (2): 79-80 Best Practices
Engel KB, Vaught J, Moore HM. National Cancer Institute Biospecimen Evidence-Based Practices: a novel approach to pre-analytical standardization Biopreserv Biobank. 2014 Apr; 12 (2): 148-50 Best Practices
Myers KS, Lockhart NC. Relationships with Outside Institutions and Industry Book chapter in Jewell S, Hansel DE (eds). Developing and Organizing an Institutional Biospecimen Repository. College of American Pathologists Press. 2014. pp. 87-96. Public-Private Relations
Moore HM. Acquisition of normal tissues for the GTEx program Biopreserv Biobank. 2013 Apr; 11 (2): 75-6. GTEx
Best Practices
Mucci N, Moore HM, Brigham LE, Goldthwaite CA, Little AR, Lockhart NC, Scott MP, Struewing JP, Vincent SL, Compton CC; cancer Human Biobank (caHUB) Acquisition of Normal Tissue Subgroup, National Cancer Institute. Meeting research needs with postmortem biospecimen donation: summary of recommendations for postmortem recovery of normal human biospecimens for research Biopreserv Biobank. 2013 Apr; 11 (2): 77-82 Best Practices
Groelz D, Sobin L, Branton P, Compton C, Wyrich R, Rainen L. Non-formalin fixative versus formalin-fixed tissue: A comparison of histology and RNA quality Exp Mol Pathol. 2013 Feb;94(1):188-94. Biospecimen Science
Vaught, J. Biospecimens in the News: Back to Basics Biopreserv Biobank. 2012 Aug; 10(4):335. Biospecimen Science
Vaught J, Lockhart N. The Evolution of Biobanking Best Practices Clinica Chimica Acta; May 2012 Best Practices
Yassin R, Weil CJ, Lockhart NC. Sharing Individual Research Results with Biospecimen Contributors: Point Cancer Epidemiology, Biomarkers and Prevention. 2012 Feb;21(2):256-9. Return of Research Data, ELSI
Lockhart NC, Yassin R, Weil CJ, Compton CC. Intersection of Biobanking and Clinical Care: Should Discrepant Diagnoses and Pathological Findings Be Returned to Research Participants? Genetics in Medicine 2012; 14 (4). Return of Research Data, ELSI
Moore, HM. The NCI Biospecimen Research Network. Biotechnic and Histochemistry Biotechnic and Histochemistry 2012 Jan: 87(1): 18-23 Biospecimen Science
Vaught J, Henderson M, Compton C. Biospecimens & Biorepositories: From afterthought to science Cancer Epidemiol Biomarkers Prev (invited editorial), 2012; 21(2): 253-255. Biospecimen Science
Rubinstein YR, Groft SC, Chandros SH, Kaneshiro J, Karp B, Lockhart NC, Marshall PA, Moxley RT 3rd, Pollen GB, Miller VR, Schwartz J. Informed consent process for patient participation in rare disease registries linked to biorepositories Contemp Clin Trials. 2012; 33(1): 5-11. Informed Consent, ELSI
Moore HM, Kelly AB, Jewell SD, McShane LM, Clark DP, Greenspan R, Hayes DF, Hainaut P, Kim P, Mansfield EA, Potapova O, Riegman P, Rubinstein Y, Seijo E, Somiari S, Watson P, Weier HU, Zhu C, Vaught J. Biospecimen reporting for improved study quality (BRISQ) Cancer Cytopathol. 2011;119:92-102 Policy and standards
Moore HM, Compton C, Alper J, Vaught JB. International approaches to advancing biospecimen science Cancer Epidemiol Biomarkers Prev, 2011; 20:729-732. International Biospecimen Science
Vaught J, Rogers J, Myers K, Lim MD, Lockhart N, Moore H, Sawyer S, Furman JL, Compton C. An NCI perspective on creating sustainable biospecimen resources J Nat Cancer Inst Monographs 2011;42:1-7 Economics of Biobanking
Vaught J, Rogers J, Carolin T, Compton C. Biobankonomics: Developing a sustainable business model approach for the formation of a human tissue biobank J Nat Cancer Inst Monographs 2011;42:24-31 Economics of Biobanking
Rogers J, Carolin T, Vaught J, Compton C. Biobankonomics: A taxonomy for evaluating the economic benefits of standardized centralized human biobanking for translational research J Nat Cancer Inst Monographs 2011;42:32-38 Economics of Biobanking
Engel KB, Moore HM. Effects of preanalytical variables on the detection of proteins by immunohistochemistry in formalin-fixed, paraffin-embedded tissue Arch Pathol Lab Med. 2011 May;135(5):537-43. PubMed PMID: 21526952 How preanalytical variation in FFPE affects IHC
Rubinstein YR, Groft SC, Bartek R, Brown K, Christensen RA, Collier E, Farber A, Farmer J, Ferguson JH, Forrest CB, Lockhart NC, McCurdy KR, Moore H, Pollen GB, Richesson R, Miller VR, Hull S, Vaught J. Creating a global rare disease patient registry linked to a rare diseases biorepository database: Rare Disease-HUB (RD-HUB). Contemp Clin Trials. 2010;31:394-404 Rare Disease Biobanking
Vaught JB, Hsing AW. Methodologic data: important foundation for molecular and biomarker studies Cancer Epidemiol Biomarkers Prev; 2010: 19: 901-902. Biospecimen Research
Vaught JB, Caboux E, Hainaut P. International efforts to develop biospecimen best practices Cancer Epidemiol Biomarkers Prev; 2010: 19:912-915 International Biospecimen Science & biobanking
Hallmans G, Vaught J. Best practices for establishing a biobank Methods in Biobanking. Methods in Molecular Biology (Methods and Protocols), vol 675. Humana Press, Totowa, NJ Biobanking
Vaught JB, Kelly AB, Hewitt R. A Review of International Biobanks & Networks: Success Factors and Key Benchmarks Biopreserv Biobank. 2010 7(3):143-150 International Biobanking
Yassin R, Lockhart N, González del Riego M, Pitt K, Thomas JW, Weiss L, Compton C. Custodianship as an ethical framework for biospecimen-based research Cancer Epidemiol Biomarkers Prev. 2010; 19(4):1012-5 Custodianship, ELSI
Moore HM, Compton CC, Lim MD, Vaught J, Christiansen KN, Alper J. 2009 Biospecimen Research Network Symposium: advancing cancer research through biospecimen science Cancer Research 2009;69;6770-2 Biospecimen Science
Robb JA, Moore HM, Compton CC. Documenting biospecimen conditions in reports of studies JAMA. 2008 Aug 13;300(6):650-1; author reply 651. PubMed PMID: 18698060. Biospecimen Collection Information & Data in publications