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Last Updated: 07/25/14

2012 BRN Symposium Agenda

Wednesday, February 22, 2012
Time Session
7:30 a.m. - 8:30 a.m. Registration — Pre-Function Area
8:30 a.m. - 8:40 a.m.

Welcome — Salons F-H

Helen M. Moore, Ph.D.
Office of Biorepositories and Biospecimen Research
National Cancer Institute, NIH
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8:40 a.m. - 9:00 a.m.

The Patient’s Perspective on Biospecimen Science

Peggy Devine. Founder and President
Cancer Information and Support Network
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9: 00 a.m. - 10:00 a.m.

Keynote Address: Pathologist Leadership in Quality Initiatives for Cancer and Biorepositories

Gene N. Herbek, M.D., FCAP
College of American Pathologists President Elect

Question-and-Answer Session
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10:00 a.m. - 10:20 a.m. Break
Session: Examining the Effects of Preanalytical Factors on Protein Expression in Tissues — Salons F-H
10:20 a.m. - 10:50 a.m.

Effects of Intra-Operative Ischemia on Cancer and Normal Tissues

Hartmut Juhl, M.D.
Indivumed

Question-and-Answer Session
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10:50 a.m. - 11:20 a.m.

Intrinsic and Extrinsic Controls for FFPE Tissue

David Rimm, M.D., PhD
Yale University

Question-and-Answer Session
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11:20 a.m. - 11:35 a.m.

Developing a Research Program to Study the FFPE Manufacturing Process

Helen Moore, Ph.D.
National Cancer Institute, NIH

Question-and-Answer Session
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11:35 a.m. - 11:50 a.m.

The Biospecimen Research Database: 1100 Articles and Growing

B. Paige Bass, Ph.D.
Kelly Government Solutions
National Cancer Institute, NIH

Questions-and-Answer Session
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11:50 a.m. - 1:30 p.m. Meet-the-Experts Working Lunch
Session: RNA Stability in Biospecimens — Salons F-H
Chair: Daniel Edelman, Ph.D.
National Cancer Institute, NIH
1:30 p.m. - 2:00 p.m.

Effects of Pre-Analytic Variables on Circulating MicroRNAs

Hua Zhao, Ph.D.
Roswell Park Cancer Institute

Question-and-Answer Session
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2:00 p.m. - 2:30 p.m.

Effects of Biospecimen Integrity, Intratumoral Heterogeneity, and Analytical Variance on Micoarray-Based Pharmacogenomics Tests of Breast Cancer

Fraser Symmans, M.D.
MD Anderson

Christos Hatzis, Ph.D.
Nuvera Biosciences

Question-and-Answer Session

2:30 p.m. - 3:00 p.m.

Measurement of RNA Integrity in Biospecimens With Sentinel Pol-II RNAs

Curt Hagedorn, M.D.
University of Utah

Question-and-Answer Session

3:00 p.m. - 3:15 p.m.

Comparison of Tissue Preservation Methods and Resulting RNA Quality in Gastrointestinal Tumors and Associated Benign Tissues

Cheryl M. Lewis, Ph.D.
University of Texas Southwestern Medical Center

3:15 p.m. - 3:30 p.m.

A Formalin Fixation Procedure that Preserves Histology and Nucleic Acid Integrity

Gianni Bussolati
University of Turin, Italy

Question-and-Answer Session
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3:30 p.m. - 3:50 p.m. Break
Session: Biospecimen Science Around the World — Salons F-H
Chair: Marianne K. Henderson, M.S.
National Cancer Institute, NIH
3:50 p.m. - 4:20 p.m.

SPIDIA Program Update

Uwe Oelmueller, Ph.D.
QIAGEN

Question-and-Answer Session
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4:20 p.m. - 4:50 p.m.

ISBER Biospecimen Working Group Update: From in silico Biospecimen Research to External Quality Assessment

Fay Betsou, Ph.D.
Integrated Biobank of Luxembourg

Question-and-Answer Session
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4:50 p.m. - 5:20 p.m.

Building Biorepositories for the United States — Latin America Cancer Research Network
Silvina Frech, Ph.D.
SAIC-Frederick Inc.
National Cancer Institute at Frederick

Question-and-Answer Session

5:20 p.m. - 5:30 p.m.

Day 1 Closing Remarks

Helen M. Moore, Ph.D.
National Cancer Institute, NIH

5:30 p.m. - 7:00 p.m. Poster Session — Salon D
Thursday, February 23, 2012
Time Session
7:30 a.m. - 8:00 a.m. Registration — Pre-Function Area
8:00 a.m. - 9:00 a.m. Meet-the-Experts Morning Working Session — Salon E
Session: Selected Abstract Presentations — Salons F-H
Chair: Nicole Moore, Ph.D.
National Cancer Institute, NIH
9:00 a.m. - 9:15 a.m.

A Physical Sciences Approach to Biospecimen Research via High Content Screening

Nicole Moore, Ph.D.
Office of Physical Sciences - Oncology
National Cancer Institute, NIH
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9:15 a.m. - 9:30 a.m.

Next-Generation Biospecimen Preservation at Ambient Temperature Based on the Use of Micron-Scale Scaffolds

Michael Hogan, Ph.D.
IntegenX Corporation
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9:30 a.m. - 9:45 a.m.

Detection and Minimization of Microheterogeneity Damage to Macromolecules During Freezing and Drying of Biospecimens

Alptekin Aksan, Ph.D.
University of Minnesota

9:45 a.m. - 10:00 a.m.

Exposing the Criminal Record of Every Blood Sample: Use of Somamer Technology and Sample Mapping Vectors to Mitigate False Biomarker Discoveries

Rachel Ostroff, Ph.D.
SomaLogic, Inc.
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10:00 a.m. - 10:15 a.m.

Preservation, Extraction, and Analysis of Biomolecules in Complex Human Biofluids

Niels H. H. Heegaard, M.D., Ph.D.
Statens Serum Institut
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10:15 a.m. - 10:30 a.m.

DNA Fragmentation Simulation Method (FSM) and Fragment Size Matching Improve aCGH Performance of FFPE Tissues

Justin M. Craig
Dana-Farber Cancer Institute

Question-and-Answer Sessions

10:30 a.m. - 10:50 a.m. Break
  Session: Measuring Protein Stability in Blood — Salons F-H
Chair: David Litwack, Ph.D.
National Cancer Institute, NIH
10:50 a.m. - 11:20 a.m.

Credentialing Plasma and Serum Biospecimen Banks for Proteomics Analyses

Katherine Williams, Ph.D.
University of California, San Francisco

Question-and-Answer Session
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11:20 a.m. - 11:50 a.m.

Investigations into the Effects of Blood Specimen Handling Procedures on Protein Integrity

Daniel Chelsky, Ph.D.
Caprion Proteomics

Question-and-Answer Session
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11:50 a.m. - 1:30 p.m. *Lunch & Poster Session
Session: The Genotype-Tissue Expression Program — Acquisition of Normal Tissue to Study Genomic Variation — Salons F-H
Chair: Stephen M. Hewitt, M.D., Ph.D.
National Cancer Institute, NIH
1:30 p.m. - 2:00 p.m.

GTEx Program Overview

Jeffery Struewing, M.D., M.S.
Simona Volpi, Ph.D., Pharm.D.
National Human Genome Research Institute, NIH

Question-and-Answer Session
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2:00 p.m. - 2:30 p.m.

Acquisition of Normal Tissues for Research

Jim Vaught, Ph.D.
Deputy Director
Office of Biorepositories and Biospecimen Research
National Cancer Institute, NIH

Question-and-Answer Session
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2:30 p.m. - 3:00 p.m.

Evaluating the Molecular Quality of Normal Tissues

Kristen Ardlie, Ph.D.
Broad Institute of MIT and Harvard

Question-and-Answer Session
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3:00 p.m. - 3:20 p.m. Break
Session: Ensuring Quality in Biospecimens — Salons F-H
Chair: Jim Vaught, Ph.D.
Deputy Director
Office of Biorepositories and Biospecimen Research
National Cancer Institute, NIH
3:20 p.m. - 3:50 p.m.

FDA perspective on Biospecimen Science

Alberto Gutierrez, Ph.D.
US Food and Drug Administration

Question-and-Answer Session

3:50 p.m. - 4:20 p.m.

College of American Pathologists’ Biorepository Accreditation Program

Denise Driscoll, M.S.
Director, Laboratory Accreditation and Regulatory Affairs
College of American Pathologists

Question-and-Answer Session
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4:20 p.m. - 4:50 p.m.

Mining the Biomedical Literature for Detailed Information About Biospecimens

Paul Fearn, M.B.A.
University of Washington

Question-and-Answer Session
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4:50 p.m.

Closing Remarks

Helen Moore, Ph.D.
National Cancer Institute, NIH

*The cost of lunch is included as a part of the registration fee, for non-Federal employees. Federal Employees must purchase their lunch at the time they submit their registration.

Biospecimen Research Network