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Last Updated: 07/25/14

2011 BRN Symposium Agenda

Monday, March 28, 2011
Time Session
7:30 a.m. - 8:30 a.m. Registration and Continental Breakfast
8:30 a.m. - 9 a.m. Welcome and BRN Program Update
Helen M. Moore, Ph.D.
National Cancer Institute, NCI
9:00 a.m. - 10:00 a.m.

Biospecimens: A Crucial Resource for Advances in Molecular Diagnostics, Imaging, and Therapeutics
George Poste, D.V.M., Ph.D., D.Sc.
Arizona State University

Question-and-Answer Session

10:00 a.m. - 10:20 a.m. Break
Session: BRN-Supported Studies in Cancer Tissue Molecular Integrity
Session Chair: Jim Vaught, Ph.D.
National Cancer Institute, NIH
10:20 a.m. - 10:50 a.m.

Effects of Intra-Operative Ischemia on Key Proteins
Hartmut Juhl, M.D., Ph.D.
Indivumed

Question-and-Answer Session

10:50 a.m. - 11:20 a.m.

Intrinsic and Extrinsic Controls for FFPE Tissue
David L. Rimm, M.D., Ph.D.
Yale University

Question-and-Answer Session

11:20 a.m. - 11:50 a.m.

Effects of Biospecimen Integrity, Intratumoral Heterogeneity, and Analytical Variance on Micoarray-Based Pharmacogenomics Tests of Breast Cancer
William Fraser Symmans, M.D.
The University of Texas M.D. Anderson Cancer Center

Christos Hatzis, Ph.D.
Nuvera Biosciences

Question-and-Answer Session

11:50 a.m. - 12:20 p.m.

Rapid Methods for the Assessment of Tissue Quality
Charles F. Saller, Ph.D.
Analytical Biological Services, Inc.

Question-and-Answer Session

12:20 p.m. - 1:45 p.m. Meet-the-Experts Lunch
Session: International Biospecimen Research and Late-Breaking Abstracts
Session Chair: Marianne K. Henderson, M.S.
National Cancer Institute, NIH
1:45 p.m. - 2:00 p.m. ISBER Initiatives in Biorepository Communication, Education, and Training
Marianne K. Henderson, M.S.
National Cancer Institute, NIH
2:00 p.m. - 2:30 p.m.

EU Project SPIDIA Update — Standardization and Improvement of Generic Preanalytical Tools and Procedures for In Vitro Diagnostics
Uwe Oelmuller, Ph.D.
QIAGEN

Question-and-Answer Session

2:30 p.m. - 2:45 p.m.

Tissue Procurement Quality Assurance in the Midwestern Division Cooperative Human Tissue Network (CHTN)
Kelly Senecal
The Ohio State University

Question-and-Answer Session

2:45 p.m. - 3:00 p.m.

A Survey of Tissue Specimen Collection Techniques: Impact on Biomarker Data Quality
Antonette Allen, M.S.
Catholic Health Initiatives Institute for Research and Innovation

Question-and-Answer Session

3:00 p.m. - 3:15 p.m.

Implementing Standard Preanalytical Coding Into the CanSto Database
Ruth Pe Benito, M.P.A.
Garvan Institute of Medical Research

Question-and-Answer Session

3:15 p.m. - 3:30 p.m.

Bringing Biobanks to Life
Richard Schlegel, M.D., Ph.D.
Georgetown University

Question-and-Answer Session

3:30 p.m. -3:50 p.m. Coffee Break
Session: Late-Breaking Abstracts in Biospecimen Science
Session Chair: Fay Betsou, Sc.D.
Integrated BioBank of Luxembourg
3:50 p.m. - 4:05 p.m.

Investigating the Impact of Preanalytical Variables on Protein Quality of Human Tissue Samples
Sibylle Guendisch, Ph.D.
Technical University of Munich

Question-and-Answer Session

4:05 p.m. - 4:20 p.m.

Snap-Embalming Tissue — Cell Signaling and Tissue Morphology Frozen in Time at Room Temperature
Claudius Mueller, Ph.D.
George Mason University

Question-and-Answer Session

4:20 p.m. - 4:35 p.m.

An Evaluation of the PAXgene Fixation System: Can We Preserve Morphology and Nucleic Acid Integrity?
William Mathieson, Ph.D., M.S.
Imperial College London

Question-and-Answer Session

4:35 p.m. - 4:50 p.m.

Glycoproteomic Analysis of Formalin-Fixed and Paraffin-Embedded Tissues and OCT-Embedded Frozen Tissues
Yuan Tian, Ph.D.
Johns Hopkins School of Medicine

Question-and-Answer Session

4:50 p.m. - 5:05 p.m.

Protocols for Analysis of Whole Saliva Gene Expression
Andrew W. Bergen, Ph.D.
SRI International

Question-and-Answer Session

5:05 p.m. - 5:20 p.m.

The Effects of Delayed Processing of Whole Blood Samples on Immune Function and Multiplex Cytokine Assays
Kerri J. Penrose
National Cancer Institute at Frederick

Question-and-Answer Session

5:20 p.m. - 5:35 p.m. Day 1 Closing Remarks
Helen M. Moore, Ph.D.
National Cancer Institute, NIH
5:35 p.m. - 7:00 p.m. Poster Session and Light Reception
Tuesday, March 29, 2011
Time Session
7:30 a.m. - 8:00 a.m. Registration and Continental Breakfast
8:00 a.m. - 9:00 a.m. Continental Breakfast Discussion Tables: Informal Discussions of Attendee-Driven Topics
Session: BRN-Supported Studies in Blood, Plasma, and Serum Molecular Integrity
Session Chair: Mark Cosentino, Ph.D., D.P.M.
National Cancer Institute at Frederick
9:00 a.m. - 9:30 a.m.

Investigations Into the Effects of Blood Specimen Handling Procedures on Protein Integrity
Daniel Chelsky, Ph.D.
Caprion Proteomics, Inc.

Question-and-Answer Session

9:30 a.m. - 10:00 a.m.

Credentialing Plasma and Serum Biospecimen Banks for Proteomics Analyses
Katherine Williams, Ph.D.
University of California, San Francisco

Susan J. Fisher, Ph.D.
University of California, San Francisco

Question-and-Answer Session

10:00 a.m. - 10:30 a.m.

Effects of Preanalytic Variables on Circulating MicroRNAs
Hua Zhao, Ph.D.
Roswell Park Cancer Institute

Question-and-Answer Session

10:30 a.m. - 10:50 a.m. Break
Session: BRN-Supported Research Studies in Cancer Tissue Preanalytical Variables
Session Chair: Helen M. Moore, Ph.D.
National Cancer Institute, NCI
10:50 a.m. - 11:20 a.m.

Project Overview and Experimental Design
Jennifer L. Hunt, M.D., M.Ed.
Massachusetts General Hospital

Question-and-Answer Session

11:20 a.m. - 11:50 a.m.

Annotating the Biospecimen Lifecycle: A Case Study
Howard Greenman, M.B.A.
Provia Laboratories

Question-and-Answer Session

11:50 a.m. - 1:30 p.m. Lunch and Poster Session

Session: Overcoming Challenges to High-Quality Biospecimen Collection
Session Chair: David G. Hicks, M.D.
University of Rochester Medical Center

1:30 p.m. - 2:00 p.m.

Empowering Community Pathologists To Successfully Conduct Molecularly Informed Personalized Medicine
Thomas P. Malone, M.B.A.
College of American Pathologists

Question-and-Answer Session

2:00 p.m. - 2:30 p.m.

The Importance of Biospecimen Quality in FDA Submissions
Abraham Tzou, M.D.
U.S. Food and Drug Administration

Question-and-Answer Session

2:30 p.m. - 3:00 p.m.

Tackling the Widespread and Critical Impact of Batch Effects in High-Throughput Data
Rafael A. Irizarry, Ph.D.
Johns Hopkins University

Question-and-Answer Session

3:00 p.m. - 3:30 p.m. Break
3:30 p.m. - 4:30 p.m.

The Revisioning of caHUB as a Center for Biospecimen Science and Standards Development
Carolyn C. Compton, M.D., Ph.D.
National Cancer Institute, NIH

Question-and-Answer Session

4:30 p.m. Closing Remarks
Helen M. Moore, Ph.D.
National Cancer Institute, NIH

Biospecimen Research Network