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Last Updated: 07/25/14

2009 BRN Symposium Agenda and Presentations

Symposium Goal:

The primary goal of the symposium is to address the impact of pre-analytical variations in the collection, handling, processing, and storage of biospecimens on cancer research and molecular medicine. The discussions of the 2009 symposium will highlight the solutions that have been developed to minimize these pre-analytical variations.

The meeting will feature expert presentations, interactive discussions and workshops from a broad range of stakeholders whose work involves biospecimens, including research investigators, clinicians, industry representatives, and patient advocates.

Monday, March 16, 2009
Time Session
7:30 a.m. - 8:30 a.m.

Registration and Continental Breakfast

Morning Chairperson: Carolyn Compton, M.D., Ph.D.
Director, Office of Biorepositories and Biospecimen Research (OBBR)
Acting Director, Office of Technology and Industrial Relations
National Cancer Institute (NCI), National Institutes of Health (NIH)

8:30 a.m. - 8:40 a.m. Welcome
Anna D. Barker, Ph.D.
Deputy Director
National Cancer Institute (NCI)
8:40 a.m. - 9:05 a.m.

The Biospecimen Research Network: Program Update and Symposium Overview
PDF Document: 1.13 MB

Helen Moore, Ph.D.
Director, Biospecimen Research Network, OBBR, NCI, NIH

Mark D. Lim, Ph.D.
PDF Document: 196 KB
AAAS Science and Technology Policy Fellow, OBBR, NCI, NIH

9:05 a.m. - 9:20 a.m. Question-and-Answer Session
9:20 a.m. - 9:45 a.m.

Pressing Issues and Opportunities in Biospecimen Science
PDF Document: 379 KB

Elizabeth Hammond, M.D., FCAP
Professor of Pathology
University of Utah School of Medicine/LDS Hospital

9:45 a.m. - 10:00 a.m. Question-and-Answer Session
10:00 a.m. - 10:15 a.m. Coffee Break
10:15 a.m. - 10:40 a.m.

The Power of the “Right” Biospecimens in Clinical Research and Care
PDF Document: 12.46 MB

David B. Agus, M.D.
Director, Spielberg Family Center for Applied Proteomics
Cedars-Sinai Medical Center

10:40 a.m. - 10:55 a.m. Question-and-Answer Session
10:55 a.m. - 11:20 a.m.

The Patient's Perspective
PDF Document: 1.39 MB

Deborah Collyar
President
Patient Advocates in Research

11:20 a.m. - 11:35 a.m. Question-and-Answer Session
11:35 a.m. - 1:00 p.m.

Meet-the-Experts lunch

Afternoon Chairperson: Mark D. Lim, Ph.D.
AAAS Science and Technology Policy Fellow, OBBR, NCI, NIH

1:00 p.m. - 1:25 p.m.

Design and Analysis of Experiments Exploring the Main Effects of Preanalytical Variables on Molecular Research
PDF Document: 100 KB

Terry Speed, Ph.D.
Professor, UC Berkeley Department of Statistics
Head, Division of Genetics and Bioinformatics, Walter and Eliza Hall Institute of Medical Research (Australia)

1:25 p.m. - 1:40 p.m. Question-and-Answer Session
1:40 p.m. - 3:00 p.m. Understanding the Molecular Effects of Handling Biofluids
1:40 p.m. - 2:05 p.m.

Biofluid Proteomics: Potential, Pitfalls, and Solutions
PDF Document: 2.26 MB

Niels Heegaard, M.D., D.Sc. (Med)
Director, Department of Autoimmunology
Statens Serum Institut (Denmark)

2:05 p.m. - 2:20 p.m. Question-and-Answer Session
2:20 p.m. - 2:45 p.m. The Need for Innovative Technology Development in the Biospecimen Sciences: The NCI IMAT program
Richard Aragon, Ph.D.
Program Director, Innovative Molecular Analysis Technologies (IMAT)
National Cancer Institute, NIH
2:45 p.m. - 3:00 p.m. Question-and-Answer Session
3:00 p.m. - 3:15 p.m. Coffee Break
3:15 p.m. - 5:15 p.m. Pre-analytical Effects of Ischemia on Tissue Biospecimens
3:15 p.m. - 3:40 p.m.

Challenges for the Development of Individualized Cancer Therapies
PDF Document: 4.03 MB

Hartmut Juhl, M.D., Ph.D.
CEO, Indivumed GmbH

3:40 p.m. - 3:55 p.m. Question-and-Answer Session
3:55 p.m. - 4:20 p.m.

Colon Biospecimens: Effects of Ischemia on Gene Expression
PDF Document: 2.47 MB

Hien Dang
Ph.D. Candidate, Pennsylvania State University

4:20 p.m. - 4:35 p.m. Question-and-Answer Session
4:35 p.m. - 5:00 p.m.

Impact of Ischemia and Tissue Procurement Conditions on Gene Expression in Renal Cell Carcinoma.
PDF Document: 10.08 MB

Gennady Bratslavsky, M.D.
Staff Urologic Surgeon
Urologic Oncology Branch, National Cancer Institute

5:00 p.m. - 5:15 p.m. Question-and-Answer Session
5:15 p.m. - 7:30 p.m. Reception and Poster Session
Tuesday, March 17, 2009
Time Session
7:30 a.m. - 8:30 a.m.

Continental Breakfast

Morning Chairperson: Helen M. Moore, Ph.D.
Director, Biospecimen Research Network, OBBR, NCI, NIH

8:30 a.m. - 8:55 a.m.

Morning Keynote - Clifton Leaf
PDF Document: 1.56 MB

Former Executive Editor, Fortune Magazine
Author, "Why We're Losing the War on Cancer (and How to Win It)"

8:55 a.m. - 9:10 a.m. Question-and-Answer Session
9:10 a.m. - 9:50 a.m.

BRN Research Contract Synopses

Effects of Biospecimen Integrity, Intramural Heterogeneity, and Analytical Variance on Microarray-Based Pharmacogenomic Tests of Breast Cancer
PDF Document: 900 KB

Christos Hatzis, Ph.D.
Nuvera Biosciences, Inc.

Investigations Into the Effects of Blood Specimen Handling Procedures on Protein Integrity
PDF Document: 32 KB

Christopher Becker, Ph.D.
PPD Biomarker Discovery Sciences

Credentialing Plasma and Serum Specimen Banks for Proteomics Analyses
PDF Document: 347 KB

Katy Williams, Ph.D.
Obstetrics, Gynecology and Reproductive Sciences
University of California, San Francisco

Extrinsic and Intrinsic Controls for Measurement of Protein Analyte Concentrations in Tissue Slides
PDF Document: 569 KB

David L. Rimm, M.D.-Ph.D.
Professor of Pathology, Yale University School of Medicine

9:50 a.m. - 10:00 a.m. Question-and-Answer Session
10:00 a.m. - 10:15 a.m. Coffee Break
10:15 a.m. - 10:40 a.m.

Pre-analytical Variables Affecting FNA and Their Influence on Clinical Diagnosis
PDF Document: 1.17 MB

Douglas P. Clark, M.D.
Director, Division of Cytopathology
John Hopkins University School of Medicine

10:40 a.m. - 10:55 a.m. Question-and-Answer Session
10:55 a.m. - 11:20 a.m.

FDA Perspective on Biospecimen Science
PDF Document: 40 KB

Elizabeth A. Mansfield, Ph.D.
Office of In Vitro Diagnostic Device Evaluation and Safety
U.S. Food and Drug Administration

11:20 a.m. - 11:35 a.m. Question-and-Answer Session
11:35 a.m. - 1:00 p.m. Lunch
1:00 p.m. - 3:00 p.m. The Use of Previously Banked Samples in R&D
Chair: Steven Gutman MD
Professor of Pathology, Univ. Central Florida
Former Director, Office of In-vitro Diagnostics (FDA)
1:00 p.m. - 1:25 p.m.

Retrospective Experimental Design and Data Analysis
PDF Document: 317 KB

Kathryn Winter, M.S.
Acting Group Statistician, Radiation Therapy Oncology Group American College of Radiology

1:25 p.m. - 1:40 p.m. Question-and-Answer Session
1:40 p.m. - 2:05 p.m.

Levels of Evidence for Retrospective Analyses of Banked Samples
PDF Document: 663 KB

Scott D. Patterson, Ph.D.
Executive Director, Medical Sciences
Amgen Inc.

2:05 p.m. - 2:20 p.m. Question-and-Answer Session
2:20 p.m. - 2:45 p.m.

Automated Nucleic Acid Isolation from FFPE Tissue and Detection of Cancer Biomarkers
PDF Document: 1.13 MB

Guido Hennig, Ph.D.
Siemens Healthcare Diagnostics Products GmbH

2:45 p.m. - 3:00 p.m. Question-and-Answer Session
3:00 p.m. - 3:15 p.m. Coffee Break
3:15 p.m. - 5:15 p.m. Gaining Access to Information About Biospecimen Science
Chair: Jim Vaught, Ph.D.
Deputy Director, OBBR, NIH
3:15 p.m. - 3:40 p.m.

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)
PDF Document: 245 KB

Lisa McShane, Ph.D.
Biometric Research Branch, Div. Cancer Treatment and Diagnosis
NCI

3:40 p.m. - 3:55 p.m. Question-and-Answer Session
3:55 p.m. - 4:20 p.m.

Opportunities and Obstacles in Publishing Biospecimen Research
PDF Document: 1.58 MB

Pierre Hainaut, PhD
Head, Molecular Carcinogenesis and Biomarkers Group
International Agency for Research on Cancer

4:20 p.m. - 4:35 p.m. Question-and-Answer Session
4:35 p.m. - 5:00 p.m.

The NCI Biospecimen Research Database
PDF Document: 788 KB

Kelly B. Engel, PhD
BRD Master Curator
Presented by Mark David Lim, Ph.D.
AAAS Science and Technology Policy Fellow, OBBR, NCI, NIH

5:00 p.m. - 5:15 p.m. Question-and-Answer Session
5:15 p.m. - 5:45 p.m.

Closing Remarks and the Next Steps
PDF Document: 3.53 MB

Carolyn C. Compton, M.D., Ph.D.
Director, Office of Biorepositories and Biospecimen Research (OBBR)
NCI

Wednesday, March 18, 2009
Time Session

Interactive Workshops

More detailed information can be found by following the Workshop Description link.

Tentative Agenda:

9:00 - 9:30 a.m. Continental Breakfast.
9:00 a.m. - 2:00 pm
(approx)

Interactive Workshops with working lunch

Workshop 1
Markers of Biospecimen Molecular Integrity

Workshop 2A/2B
Evidence-based Protocols

Workshop 3A/3B
Publishing in Biospecimen Science

2:00 - 2:30 p.m. Chair Discussion (all participants invited)

Biospecimen Research Network