Skip to Content
Last Updated: 07/25/14

2008 BRN Symposium Agenda and Presentations

Symposium Goal:

The primary goal of the symposium is to address the significant impact of pre-analytical biospecimen variability on cancer research and molecular medicine.

The meeting will feature expert presentations and interactive discussions from a broad range of stakeholders whose work involves biospecimens, including research investigators, clinicians, industry representatives, hospital administrators and patient advocates.

Thursday, March 13, 2008
Time Session
7:30 a.m. - 8:30 a.m. Registration and Continental Breakfast
8:30 a.m. - 8:45 a.m. Welcome
Anna D. Barker, Ph.D.
Deputy Director
National Cancer Institute (NCI)
Director
Advanced Technologies and Strategic Partnerships
8:45 a.m. - 9:15 a.m.

The Importance of High-Quality Biospecimens to the Research Enterprise
PDF Document: 1.63 MB

Carolyn C. Compton, M.D., Ph.D.
Director, Office of Biorepositories and Biospecimen Research (OBBR)
Acting Director, Office of Technology and Industrial Relations (OTIR)
Office of the Director, NCI

9:15 a.m. - 9:30 a.m. Question-and-Answer Session
9:30 a.m. - 10:00 a.m.

The Role of Biospecimens in Biomarker Research: Challenges and Opportunities
PDF Document: 1.74 MB

David F. Ransohoff, M.D.
Professor of Medicine and Clinical Professor of Epidemiology
University of North Carolina at Chapel Hill

10:00 a.m. - 10:15 a.m. Question-and-Answer Session
10:15 a.m. - 10:30 a.m. Break
10:30 a.m. - 12 noon

Lessons Learned: Effects of Biospecimen Quality on Genomic and Proteomic Research

Carolyn C. Compton, M.D., Ph.D.
Director, OBBR
Acting Director, OTIR
Office of the Director, NCI

10:30 a.m. - 11:00 a.m.

Pitfalls and Gaps in Research Using Human Biospecimens
PDF Document: 974 KB

Patrick O. Brown, M.D., Ph.D.
Investigator
Howard Hughes Medical Institute
Department of Biochemistry
Beckman Center for Molecular and Genetic Medicine
Stanford University Medical Center

11:00 a.m. - 11:15 a.m. Question-and-Answer Session
11:15 a.m. - 11:45 a.m.

Critical Pre-Analytical Variables in the Real World of Tissue Procurement
PDF Document: 4.52 MB

Lance Liotta, M.D., Ph.D.
University Professor, Life Sciences
Co-Director, Center for Applied Proteomics and Molecular Medicine
George Mason University

11:45 a.m. - 12 noon Question-and-Answer Session
12 noon - 1:15 p.m. Hosted Lunch Tables: Meet the Experts
(Lunch will be available for purchase.)
1:15 p.m. - 2:45 p.m.

HER2/neu: Lessons Learned From Paired Diagnostics and Therapeutics

Session Chair:
Elizabeth Hammond, M.D., FCAP
Professor of Pathology
University of Utah School of Medicine/LDS Hospital

Presentations and Panel Discussion:
1:15 p.m. - 1:35 p.m. Paul Waring, M.D., Ph.D., M.B.B.S.
Senior Director of Pathology and Diagnostics
Genentech, Inc.
1:35 p.m. - 1:55 p.m.

Measurement of HER2
PDF Document: 789 KB

Daniel F. Hayes, M.D.
Clinical Director, Breast Oncology Program
Professor, University of Michigan Comprehensive Cancer Center

1:55 p.m. - 2:15 p.m.

Molecular Diversity of Human Breast Cancers
PDF Document: 1.95 MB

Dennis J. Slamon, M.D., Ph.D.
Director, Clinical/Translational Research
Jonsson Comprehensive Cancer Center
Professor of Medicine and Chief
Division of Hematology and Oncology
David Geffen School of Medicine
University of California, Los Angeles

2:15 p.m. - 2:45 p.m. Panel Discussion
2:45 p.m. - 3:00 p.m. Break
3:00 p.m. - 5:00 p.m.

Research Advances in Biospecimen Science I

Session Chair:
Scott Jewell, Ph.D.
Associate Professor, Department of Pathology,
College of Medicine
The Ohio State University

3:00 p.m. - 3:20 p.m.

The NCI Biospecimen Research Network and Literature Database
PDF Document: 756 KB

Helen Moore, Ph.D.
Director, Biospecimen Research Network
OBBR, NCI

3:20 p.m. - 3:30 p.m. Question-and-Answer Session
3:30 p.m. - 3:50 p.m. Influence of Cellular Heterogeneity in Carcinoma Specimens for Identification of Clinically Relevant Molecular Signatures
James L. Wittliff, Ph.D., M.D. hc
Professor of Biochemistry and Molecular Biology
James Graham Brown Cancer Center
University of Louisville
3:50 p.m. - 4:00 p.m. Question-and-Answer Session
4:00 p.m. - 4:20 p.m.

Effects of Fixation vs. Tissue Processing on Immunohistochemical Analysis
PDF Document: 1.55 MB

William E. Grizzle, M.D., Ph.D.
Professor, Department of Pathology
University of Alabama at Birmingham

4:20 p.m. - 4:30 p.m. Question-and-Answer Session
4:30 p.m. - 4:50 p.m. Proteomic Discovery in Archived Tissue Blocks
Brian M. Balgley, M.D., Ph.D.
Chief Technical Officer
Calibrant Biosystems, Inc.
4:50 p.m. - 5:00 p.m. Question-and-Answer Session
5:00 p.m. - 5:15 p.m. Day 1 Wrap-Up
Carolyn C. Compton, M.D., Ph.D.
Director, OBBR
Acting Director, OTIR
Office of the Director, NCI
5:15 p.m. - 7:00 p.m. Poster Session and Reception
Poster presenters may begin to set up their posters starting at 4:00 p.m.
Friday, March 14, 2008
Time Session
7:30 a.m. - 8:30 a.m. Registration and Continental Breakfast
8:30 a.m. - 9:00 a.m.

Locking in Pre-Analytical and Post-Analytical Performance: Being Pound Wise, Not Penny Foolish
PDF Document: 46 KB

Steve Gutman, M.D.
Director
Office of In Vitro Diagnostic Device Evaluation and Safety (OVID)
Center for Devices and Radiological Health
Food and Drug Administration (FDA)

9:00 a.m. - 9:15 a.m. Question-and-Answer Session
9:15 a.m. - 9:35 a.m.

Patients' Perspective on Biospecimen Quality
PDF Document: 492 KB

Paula Kim
Chief Executive Officer
Translating Research Across Communities

9:35 a.m. - 9:45 a.m. Question-and-Answer Session
9:45 a.m. - 10:00 a.m. Break
10:00 a.m. - 11:30 a.m.

Assessing and Qualifying Biospecimen Quality

Session Chair:
Steven Gutman, M.D.
Director, OVID, FDA

10:00 a.m. - 10:20 a.m.

Signal:Noise? The Importance of the Pre-Analytical Phase in Sample Storage
PDF Document: 292 KB

Scott D. Patterson, Ph.D.
Executive Director, Medical Sciences
Amgen Inc.

10:20 a.m. - 10:30 a.m. Question-and-Answer Session
10:30 a.m. - 10:50 a.m.

Pre-Analytical Variables in Validation of Methylated Biomarkers in Blood Plasma
PDF Document: 730 KB

Theo deVos, Ph.D., M.S.P.H.
Vice President, Development Diagnostics
Epigenomics, Inc.

10:50 a.m. - 11:00 a.m. Question-and-Answer Session
11:00 a.m. - 11:20 a.m.

Measuring Biomarker Stability in Frozen Tissue
PDF Document: 574 KB

Scott Jewell, Ph.D.
Associate Professor, Department of Pathology
College of Medicine
The Ohio State University

11:20 a.m. - 11:30 a.m. Question-and-Answer Session
11:30 a.m. - 12:30 p.m. Lunch
(Lunch will be available for purchase.)
12:30 p.m. - 2:00 p.m.

Research Advances in Biospecimen Science II

Session Chair:
William Grizzle, M.D., Ph.D.
Professor, Department of Pathology
University of Alabama at Birmingham

12:30 p.m. - 12:50 p.m.

Overcoming Challenges to Tissue-Based Studies
PDF Document: 5.64 MB

Christopher J. Logothetis, M.D.
Chair, Department of Genitourinary Medical Oncology,
The University of Texas M. D. Anderson Cancer Center

12:50 p.m. - 1:00 p.m. Question-and-Answer Session
1:00 p.m. - 1:20 p.m.

Nonpatient-Related Variables Affecting Detection of VEGF in Urine Biospecimens
PDF Document: 186 KB

Kevin Camphausen, M.D.
Chief, Radiation Oncology Branch
Head, Imaging and Molecular Therapeutics Section
NCI

1:20 p.m. - 1:30 p.m. Question-and-Answer Session
1:30 p.m. - 1:50 p.m.

Defining Optimal Tissue Handling Procedures for Multiplex In Vitro Diagnostics
PDF Document: 568 KB

Guido Brink, M.S.
Director, Quality Management and Regulatory Affairs
Agendia, BV

1:50 p.m. - 2:00 p.m. Question-and-Answer Session
2:00 p.m. - 2:15 p.m. Break
2:15 p.m. - 3:45 p.m.

Incorporating Biospecimen Science Into Research Practice: Opportunities, Challenges, and Progress

Session Chair:
Kevin Camphausen, M.D.
Head, Imaging and Molecular Therapeutics Section
Chief, Radiation Oncology Branch
NCI

2:15 p.m. - 2:35 p.m.

Harmonizing Biospecimen Best Practices Across the Prostate SPORES
PDF Document: 1.22 MB

Angelo M. De Marzo M.D., Ph.D.
Director, Tissue Microarray Core Facility
Associate Director of Cancer Research Pathology
Associate Professor of Pathology, Oncology, and Urology
Johns Hopkins University

2:35 p.m. - 2:45 p.m. Question-and-Answer Session
2:45 p.m. - 3:05 p.m.

Practical Applications of Biospecimen Science in Biobanking
PDF Document: 639 KB

Gerry Thomas, Ph.D.
Professor of Molecular Pathology
Imperial College London

3:05 p.m. - 3:15 p.m. Question-and-Answer Session
3:15 p.m. - 3:35 p.m.

CAP: Preparing Pathologists
PDF Document: 373 KB

Elizabeth Hammond, M.D., FCAP
Professor of Pathology
University of Utah School of Medicine/LDS Hospital

3:35 p.m. - 3:45 p.m. Question-and-Answer Session
3:45 p.m. - 4:15 p.m. General Question-and-Answer Session
4:15 p.m. - 4:30 p.m. Closing Remarks
Carolyn C. Compton, M.D., Ph.D.
Director, OBBR
Acting Director, OTIR
Office of the Director, NCI

Biospecimen Research Network